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Drugs that primarily affect Beta-1 receptors are specifically designed to target the heart. These receptors are a subtype of adrenergic receptors that, when activated, predominantly influence cardiac function. Stimulation of Beta-1 receptors increases heart rate (positive chronotropic effect) and enhances the force of heart contractions (positive inotropic effect). This makes Beta-1 receptor antagonists (beta-blockers) particularly useful in managing conditions such as hypertension, heart failure, and arrhythmias by decreasing cardiac workload and oxygen consumption.

While other organs, such as the kidneys, have some interaction with Beta-1 receptors, they do so in a more secondary context, mainly related to the regulation of renin release which affects blood pressure. In contrast, the heart is the primary organ where the effects of Beta-1 modulation are most pronounced, demonstrating the vital role these receptors play in cardiovascular health.