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Abdominal compartment syndrome is a significant complication that can arise in multi-organ donors, particularly those with abdominal injuries. This condition occurs when there is increased pressure within the abdominal cavity, which can compromise the function of abdominal organs and lead to multiple organ dysfunction. In the context of multi-organ donation, identifying and managing this syndrome is crucial because it can affect the viability of harvested organs, especially the kidneys and liver.

In trauma cases, especially with significant abdominal injuries, the accumulation of blood, fluid, or tissue swelling can lead to elevated intra-abdominal pressure. This can impede venous return, reduce cardiac output, and ultimately compromise respiratory function as well. The diagnosis and management of abdominal compartment syndrome are therefore essential to maintain organ perfusion and function, further facilitating successful transplantation outcomes.

Other potential complications, while relevant in various clinical settings, are less directly associated with the acute conditions of multi-organ donors due to abdominal injuries.